Prevention and prediction of oral carcinogenesis for betel quid chewers

2012 Fiscal Year Final Research Report

• Project/Area Number: 21406030
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Surgical dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: CHIBA Itsuro 北海道医療大学, 歯学部, 教授 (50250460)
• Co-Investigator(Kenkyū-buntansha): ABIKO Yoshihiro 北海道医療大学, 医科学センター, 教授 (90260819)
• Project Period (FY): 2009 – 2012
• Keywords: 口腔がん / 予防 / 介入研究 / スリ / ランカ / バイオマーカー

Research Abstract

Intervention study using anti-oxidant has performed in betel quid chewers who have oral precancer and the lesion size was significantly decreased.

Research Products

• [Journal Article] Lipopolysaccharide extracted from Porphyromonas gingivalis induces DNA hypermethylation of runt-related transcription factor 2 in human periodontal fibroblasts (2012)
  • Author(s): Uehara O, Abiko Y, Saitoh M, Miyakawa H, Nakazawa F
  • Journal Title: J Microbiol Immunol Infect
• [Journal Article] Expression profile of drosomycin-like defencin in oral epithelium and oral carcinoma cell lines (2012)
  • Author(s): Sato J., Nishimura M., Yamazaki M., Yoshida K., Kurashige Y., Saitoh M., Abiko Y
  • Journal Title: Arch. Oral Biol Volume: (Epub ahead of print) Pages: S0003-9969
• [Journal Article] A polymerase chain reaction-based method for constructing a linear vector with site-specific DNA methylation (2011)
  • Author(s): Arakawa T, Ohta T, Abiko Y, Okayama M, Mizoguchi I, Takuma T
  • Journal Title: Anal Biochem Volume: 416(2):211-7
• [Journal Article] Association between self-efficacy and loss to follow-up in long-term periodontal treatment (2010)
  • Author(s): Kakudate N, Morita M, Yamazaki S, Fukuhara S, Sugai M, Nagayama M, Kawanami M, Chiba I
  • Journal Title: J Clin Periodontol Volume: 37(3):276-82
• [Presentation] Curcumin is an effective chemopreventive substance for betel quid chewer's oral precancer in Sri Lanka (2012)
  • Author(s): I Chiba, M Muthumala, C Sugiura, M Onodera, T Shibata, H Matsuoka, N Kakudate, Shunichi Fukuhara, T Takiguchi, M Takeshima, Y Abiko, H Kobayashi
  • Organizer: AACR
  • Place of Presentation: Anaheim, CA
  • Year and Date: 20121016-19