2011 Fiscal Year Final Research Report
Regulation of axonal transport by local interaction with myelin
| Project/Area Number |
21500355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
BABA Hiroko 東京薬科大学, 薬学部, 教授 (40271499)
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| Project Period (FY) |
2009 – 2011
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| Keywords | グリア細胞 |
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| Research Abstract |
In order to elucidate the role of myelin on axonal transport, immunohistological and biochemical analyses were performed in the central and peripheral nervous systems of myelin mutant mice. In these mice, paranodal axo-glial junctions(AGJ) were disrupted but compact myelin was preserved. The present results demonstrated that disruption of AGJ caused local axonal swellings containing various axonal components and changes of axonal transport-related molecules. Involvement of local calcium change was suggested. Focal axonal swellings were first observed at early stage of myelination and progressive with age. Axonal degeneration became more prominent in aged mice. Thus, the axo-glial interaction at the paranode is important for local axonal homeostasis.
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