2011 Fiscal Year Final Research Report
Study of the switching mechanism by which microglia change their function
| Project/Area Number |
21500357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Soka University |
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Principal Investigator |
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| Research Collaborator |
YAMAMOTO Shinichi 創価大学, 大学院・工学研究科, 大学院生
MAEDA Shyuichi 創価大学, 大学院・工学研究科, 大学院生
YOSHINO Yukihisa 創価大学, 大学院・工学研究科, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経科学 / 脳・神経 / グリア細胞 / 免疫 |
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| Research Abstract |
The ability of microglia to proliferate, produce harmful factors, express phagocytic properties and present antigens has been considered to be switched on/off by intracellular signal transduction mechanism. However, the experiments using rat facial nerve transection model and in vitro model revealed that the abilities of microglia were suggested to be switched on/off by specific factors present in extracellular space, but not by intracellular signal transduction mechanism.
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