2012 Fiscal Year Final Research Report
Glutamate receptor-dependent regulation in hippocampal neurogenesis focused on NMDA receptor
| Project/Area Number |
21500366
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Bunkyo University (2010-2012)
Gunma University (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIUCHI Shogo 琉球大学, 医学研究科, 教授 (10312878)
YOSHIDA Yukari 群馬大学, 重粒子線医学センター, 助教 (90431717)
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| Project Period (FY) |
2009 – 2012
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| Keywords | ニューロン / シナプス / 神経回路 |
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| Research Abstract |
Glutamate receptors of NMDA and AMPA type control emotional expressions by regulating hippocampal neurogenesis in the dentate gyrus. Blockings of NMDA receptors and activations of Ca2+-permeable AMPA receptors facilitated neurogenesis. Reduced anxiety was observed in GRIA2 disrupted mice, which lack GluA2 subunit of the AMPA receptor, in elevated plus maze task. Blocking of neurogenesis by X-ray irradiation did not increase the degrees of anxiety in these mice.
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