2011 Fiscal Year Final Research Report
Development of an in vivo induction method of synaptic plasticity.
| Project/Area Number |
21500367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NOGUCHI Jun 東京大学, 大学院・医学系研究科, 特任助教 (40421367)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ニューロン / シナプス / 神経回路 / in vivo |
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| Research Abstract |
We developed a methodology for in vivo administration of neurotransmitter glutamate which mimics glutamates that is released from presynaptic terminals. We found that in adult mouse L2/3 pyramidal neurons, distribution of functional AMPA receptors on spines was proportional to the spine volume. Then we found that repetitive stimulation of a dendritic spine of a living adult mouse caused long-term shrinkage of the spine which lasted 1 hour or more. Thus we could successfully induce long-term plasticity of spine volume, in other words, synaptic plasticity.
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