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2012 Fiscal Year Final Research Report

Roles of monoaminergic and secretinergic regulations of synaptic transmission in cerebellar inhibitory synapses

Research Project

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Project/Area Number 21500375
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionNippon Medical School

Principal Investigator

SAITOW Fumihito  日本医科大学, 医学部, 准教授 (20360175)

Co-Investigator(Kenkyū-buntansha) 永野 昌俊  日本医科大学, 医学部, 講師 (60271350)
Project Period (FY) 2009 – 2012
Keywordsニューロン / シナプス / 神経回路
Research Abstract

In this study, we examined a role of monoamines (noradrenaline (NA) and dopamine (DA)) and secretin on the synaptic transmission using rat cerebellum. 1) Pharmacological study revealed that presynaptic α2-adrenergic (α2-AR) and D2-like receptors (D2R) were activated by both NA and DA. Therefore, it is thought that cross-talk between these receptors play a role of sharing the modulatory action involving distinct monoaminergic controls in the cerebellum. 2) It is well known that neuropeptide secretin increases GABA release involving an activation of cAMP-PKA signal cascade onto inhibitory synapses at the cerebellar cortex. We found that new form of synaptic modulation involving the activation ofPLC-IP3 signal pathway at GABAergic synaptic terminals.

  • Research Products

    (20 results)

All 2013 2012 2011 2010 2009

All Journal Article (5 results) Presentation (14 results) Book (1 results)

  • [Journal Article] Electrophysiological and pharmacological properties of GABAergic cells in the dorsal raphe nucleus.2013

    • Author(s)
      Gocho Y, Sakai A, Yanagawa Y, Suzuki H, Saitow F.
    • Journal Title

      J Physiol. Sci

      Volume: 63 Pages: 147-54

  • [Journal Article] Cerebellar globular cells receive monoaminergic excitation and monosynaptic inhibition from Purkinje cells.2012

    • Author(s)
      Hirono M, Saitow F , Kudo M, Suzuki H, Yanagawa Y, Yamada M, Nagao S, Konishi S, Obata K.
    • Journal Title

      PLoS One

      Volume: 7 Pages: e29663

  • [Journal Article] Modulatory effects of serotonin on glutamatergic synaptic transmission and long-term depression in the deep cerebellar nuclei.2011

    • Author(s)
      Murano M, Saitow F, Suzuki H
    • Journal Title

      Neuroscience

      Volume: 172 Pages: 118-128

  • [Journal Article] Effects of stress memory by fear conditioning on nerve-mast cell circuit in skin.2011

    • Author(s)
      Kumagai M, Nagano M , Suzuki H, Kawana S.
    • Journal Title

      J Dermatol

      Volume: 38 Pages: 533-561

  • [Journal Article] Murakoshi T Chronic stress enhances synaptic plasticity due to disinhibition in the anterior cingulate cortex and induces hyper-locomotion in mice.2010

    • Author(s)
      Ito H, Nagano M, SuzukiH
    • Journal Title

      Neuropharmacology

      Volume: 58 Pages: 746-757

  • [Presentation] マウス背側縫線核におけるニューロンの電気生理学的特性2013

    • Author(s)
      牛腸義宏ほか
    • Organizer
      日本生理学会大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      20130327-29
  • [Presentation] 縫線核におけるGABA作動2012

    • Author(s)
      牛腸義宏ほか
    • Organizer
      性ニューロンの形態的特徴と電気生理学的特性の解析日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      20120918-21
  • [Presentation] 小脳核苔状線維におけるモノアミン作動性受容体のク2012

    • Author(s)
      齋藤文仁ほか
    • Organizer
      ロストーク活性アミンに関するワークショップ
    • Place of Presentation
      北海道医療大学
    • Year and Date
      2012-08-24
  • [Presentation] マカクザルtachykinin受容体NK-1,NK-2,NK-3の中枢での発現分布と薬理学的性質2012

    • Author(s)
      永野昌俊ほか
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2012-03-16
  • [Presentation] 小脳グロビュラー細胞へのシナプス2011

    • Author(s)
      廣野守俊ほか
    • Organizer
      入力の研究第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-09-17
  • [Presentation] 小脳グロビュラー細胞へのシナプス入力の研究2011

    • Author(s)
      廣野守俊ほか
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-09-17
  • [Presentation] プルキンエ細胞の脱分極による2011

    • Author(s)
      佐藤寛栄ほか
    • Organizer
      IPSCの抑制第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-09-16
  • [Presentation] プルキンエ細胞の脱分極によるIPSCの抑制2011

    • Author(s)
      佐藤寛栄ほか
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-09-16
  • [Presentation] Effects of early intervention with fluoxetine on anxiety-related behaviors induced in prenatally glucocorticoid exposed rats.2010

    • Author(s)
      Nagano M et al.
    • Organizer
      16th World Congress of Basic and Clinical Pharmacology (WorldPharma 2010)
    • Place of Presentation
      Copenhagen
    • Year and Date
      20100717-23
  • [Presentation] 小脳核苔状線維シナプスのセロトニンを介したシナプス可塑性調節機構2010

    • Author(s)
      齋藤文仁ほか
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      20100519-21
  • [Presentation] 小脳プルキンエ細胞から強い抑制を受ける顆粒層小型抑制性介在ニューロンの解明2010

    • Author(s)
      廣野守俊ほか
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      20100519-21
  • [Presentation] 小脳核グルタミン酸作動性シナプスにおけるモノアミンを介した修飾作用2009

    • Author(s)
      齋藤文仁ほか
    • Organizer
      第47回日本生物物理学会年会
    • Place of Presentation
      アクティとくしま
    • Year and Date
      2009-10-30
  • [Presentation] Monoaminergic cross-talk and mudulatory action of synaptic transmission in the deep cerebellar nuclei.2009

    • Author(s)
      Saitow F et al.
    • Organizer
      36回IUPS(国際生理学大会)
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-07-28
  • [Presentation] Monoaminergic cross-talk and mudulatory action of synaptic transmission in the deep cerebellar nuclei.2009

    • Author(s)
      Saitow F et al.
    • Organizer
      36回国際生理学大会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-07-28
  • [Book] Serotonin and Synaptic Transmission in the cerebellum. In Handbook of the Cerebellum and Cerebellar Disorders2012

    • Author(s)
      Saitow F, Hirono M, Suzuki H.
    • Publisher
      Manto M, Gruol DL, Schmahmann JD, Koibuchi N, Rossi F.

URL: 

Published: 2014-08-29  

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