2011 Fiscal Year Final Research Report

The creation and application of lifestyle-related diseases in the hyperlipidemia mouse.

Research Project

Project/Area Number	21500392
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Laboratory animal science
Research Institution	Minami Kyusyu University
Principal Investigator	ITO Kaoru 南九州大学, 健康栄養学部, 教授 (70341633)
Co-Investigator(Renkei-kenkyūsha)	KOSHIMOTO Chihiro 宮崎大学, フロンティア科学実験総合センター, 教授 (70295210) ITO Katsuaki 宮崎大学, 農学部, 名誉教授 (70136795)
Project Period (FY)	2009 – 2011
Keywords	疾患モデル / 高脂血症 / 血管機能 / 動脈硬化 / 循環器・高血圧
Research Abstract	We evaluated the effect of high cholesterol diet on endothelial function of artery from European wood mice(Apodemus Sylvaticus), some of which spontaneously exhibit hyperlipidemia on a normal diet. According to the plasma cholesterol level, mice were divided into two groups ; hypercholesterol mice and normocholesterol mice. Both mice were fed with a normal or high-cholesterol diet for 5 weeks. The high-cholesterol diet increased the total plasma cholesterol level in both groups. The endothelium-dependent relaxation of isolated aorta was worsened in both mice after high cholesterol feeding. Thus, the endothelium-dependent relaxation was inhibited depending on the total plasma cholesterol level.

(3 results)