2011 Fiscal Year Final Research Report

Finding the novel anti-metabolic syndrome treatment by examining the mechanism of improvement for lipid metabolism with hyperbaric oxygen.

Research Project

Project/Area Number	21500685
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Applied health science
Research Institution	Saitama Medical University (2011) The University of Tokushima (2009-2010)
Principal Investigator	HOSAKA Toshio 埼玉医科大学, 医学部, 講師 (60403698)
Co-Investigator(Kenkyū-buntansha)	NAKAYA Yutaka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (50136222)
Research Collaborator	INUAKI Kouichi 杏林大学, 大学院・医学研究科, 准教授 (20333007)
Project Period (FY)	2009 – 2011
Keywords	生活習慣病
Research Abstract	Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after chronic treatments with HBA(hyperbaric air). The mRNA expressions related to lipid metabolism were significantly up-regulated in the muscle and liver. Increases in adipocytokine mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with obesity and metabolic syndrome and then, belong to the finding of new targets of treatment.