Development of the diet therapy considering polymorphisms of metabolic syndrome related gene

2011 Fiscal Year Final Research Report

• Project/Area Number: 21500794
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kagawa Nutrition University
• Principal Investigator: TANAKA Akira 女子栄養大学, 栄養学部, 教授 (70171733)
• Project Period (FY): 2009 – 2011
• Keywords: メタボリックシンドローム / 食事療法 / 遺伝子多型 / アンギオテンシノーゲン / アドレナリンβ3受容体 / 脱共役たんぱく質

Research Abstract

The intervention study by diet and exercise therapy for 6 months was performed in 101 patients with metabolic syndrome. The effects of polymorphisms of hypertension related gene, angiotensinogen gene and obesity related gene, adrenalin β3 receptor(Adβ3R) gene and uncoupling protein-1(UCP-1) gene on the change of metabolic syndrome related factors during the intervention were investigated.
Considering the results of the study, the effects of diet and exercise therapy on metabolic syndrome related factors may be larger than that of polymorphism of metabolic syndrome related gene.

Research Products

• [Journal Article] Measurement of serum remnant-like lipoprotein particle-triglyceride(RLP-TG) and RLP-TG/ total TG ratio using highly sensitive triglyceride assay reagent (2011)
  • Author(s): Nakano T, Tokita Y, Nagamine T Tanaka A, Okazaki M, Yatsuzuka S, Tamei N, Shimomura Y, Ando Y, Akamatsu S, Fujita Q M, Nakajima K
  • Journal Title: Clin Chim Acta Volume: 412 Pages: 71-78
  • Peer Reviewed
• [Journal Article] Particle size of apoB-48 carrying lipoproteins in remnant lipoproteins isolated from postprandial plasma (2011)
  • Author(s): Nakano T, Tanaka A, Okazaki M, Tokita Y, Nagamine T, Nakajima K
  • Journal Title: Annals of Clinical Biochemistry Volume: 48 Pages: 57-64
  • Peer Reviewed
• [Journal Article] Postprandial lipoprotein metabolism ; VLDLvs chylomicrons (2011)
  • Author(s): Nakajima K, Nakano T, Tokita Y, nagamine T, Inazu A, Kobayashi J, Mabuchi H, Stanhope KL, Havel PJ, Okazaki M, Tanaka A
  • Journal Title: Clin Chim Acta Volume: 421 Pages: 1306-1318
  • Peer Reviewed
• [Journal Article] Delayed postprandial metabolism of triglyceride-rich lipoproteins in obese young men compared to lean young men (2010)
  • Author(s): Kaeriyama Nabeno Y, Fukuchi Y, Hayashi S, Kimura T, Tanaka A, Naito M
  • Journal Title: Clin chim Acta Volume: 411 Pages: 1694-1699
  • Peer Reviewed
• [Journal Article] A new Japanese vegetarian food guide (2009)
  • Author(s): Keiko Nakamoto, Sanae Watanabe, Hideki Kudo, Akira Tanaka
  • Journal Title: Asia-Pacific Journal of Public Health21 Volume: 2 Pages: 160-169
  • Peer Reviewed
• [Journal Article] Effects of IntensiveAtorvastatin and RosuvastatinTreatment on Apolipoprotein B-48 and Remnant Lipoprotein Cholesterol Levels (2009)
  • Author(s): Otokozawa S, Ai M, van Himbergen T, Asztalos BF, Tanaka A, SteinEA, Jones PH, Schaefer EJ
  • Journal Title: Atherosclerosis Volume: 205(1) Pages: 197-201
  • Peer Reviewed
• [Journal Article] Fasting and Posprandial Apolipoprotein B-48 Levels in Normal, Obese, and Hyperlipidemic Subjects (2009)
  • Author(s): Otokozawa S, Ai M, Diffenderfer MR, Tanaka A, Lamon-Fava S, Scaefer EJ
  • Journal Title: Metabolism Volume: 58 Pages: 1536-1542
  • Peer Reviewed
• [Journal Article] A deficiency of cholesteryl ester transfer protein whose serum remnant-like particle(RLP)-triglyceride significantly increased, but RLP-cholesterol did not after an oral fat load (2009)
  • Author(s): Ai M, Tanaka A, Shimokado K, Inazu A, Kobayashi J, Mabuchi H, Nakano T, Nakajima K
  • Journal Title: Ann Clin Biochem Volume: 46 Pages: 457-463
  • Peer Reviewed
• [Journal Article] The characteristics of remnant lipoproteins in the fasting and postprandial plasma
  • Author(s): Nakano T, Nakajima K, Nagamine T, Tokita Y, Sumino H, Nara M, Machda T, Murakami M, Shimomura T, Yatsuzuka S, Tanaka A
  • Journal Title: Clin Chim Acta Volume: (in press)
  • Peer Reviewed
• [Journal Article] Post-prandial Remnant Lipoprotein Metabolism in Autosomal Recessive Hypercholesterolemia
  • Author(s): Tada Hyato, Kawashiri Masa-aki, Tanaka Akira, Nakano Takamitsu, Nakajima Katsuyuki, Noguchi Tohru, Nakanishi Chiaki, Konno Tetsuo, Hayashi Kenshi, Nohara Atsushi, Inazu Akihiro, Kobayashi Junji, Mabuchi Hiroshi, Mamagishi Masakazu.
  • Journal Title: Eur J Clin Invest Volume: (in press)
  • Peer Reviewed
• [Presentation] 2型糖尿病と肥満がリポ蛋白亜分画に及ぼす影響に関する検討 (2012)
  • Author(s): 藍真澄、朝長修、小川智也、山崎瑞樹、田中明、岡崎三代、吉田雅幸
  • Organizer: 第55回日本糖尿病学会
  • Place of Presentation: 横浜
  • Year and Date: 20120517-19
• [Presentation] 糖尿病患者の栄養教育に使用する食事療法用宅配食品の有効性の検討(第2報) (2012)
  • Author(s): 井部奈生子、井上正子、粕谷健司、田中明
  • Organizer: 第15回日本病態栄養学会
  • Place of Presentation: 京都
  • Year and Date: 20120114-15
• [Presentation] 減量コース受講中の肥満女性におけるIL6(rs8192284)遺伝子多型と身体計測・生化学検査の関連性 (2012)
  • Author(s): 平井千里、石井由香、石塚陽子、蒲池桂子、田中明、香川靖雄
  • Organizer: 第15回日本病態栄養学会
  • Place of Presentation: 京都
  • Year and Date: 20120114-15
• [Presentation] メタボリックシンドロームを反映する指標の検討 (2012)
  • Author(s): 八田真奈、蒲池桂子、竹下尚男、富江尚子、春日千加子、榊玲里、辻谷真理子、五位渕可菜、加藤千草、香川靖雄、藍真澄、片嶋充弘、田中明
  • Organizer: 第15回日本病態栄養学会
  • Place of Presentation: 京都
  • Year and Date: 20120114-15
• [Presentation] Long-Term Consumption of Catechin-Rich Beverage Has No Impact on Liver Function.% th Annual Meeting & ToxExpo (2012)
  • Author(s): Takeshita M, Kamachi K, Yatsuda M, Kasuga C, Tsujitani M, Kato C, Katashina M, Ai M, Tanaka A
  • Organizer: Society of Toxicology
  • Place of Presentation: San Francisco
  • Year and Date: 2012-03-13
• [Presentation] Relationship between serum concentrations of small dense Low-density lipoprotein-cholesterol and chplesterol absorption and synthesis markers (2011)
  • Author(s): Ai M, Tomonaga O, Ogawa T, Yamazaki T, Doi R, Itoh A, Usuda Y, Ito Y, Tomie N, Tanaka A, Yoshida M
  • Organizer: 第43回日本動脈硬化学会
  • Place of Presentation: 札幌
  • Year and Date: 20110715-16
• [Presentation] The presence of remnant lipoproteins in plasma with TG levels less than 150 mg/ dl (2011)
  • Author(s): Nakajima K, Nakano T, Tokita Y, Nagamine T, Yatsuzuka S, ShimomuraY, Tanaka A
  • Organizer: 第43回日本動脈硬化学会
  • Place of Presentation: 札幌
  • Year and Date: 20110715-16
• [Presentation] The presence of remnant lipoproteins in the fasting plasma with TG levels less than 150mg/ dL (2011)
  • Author(s): Nakajima K, Nakano T, Tokita Y, Nagamine T, Yatsuzuka S, Shimomura Y, Tanaka A
  • Organizer: 79th European Atherosclerosis Society Congress
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 20110626-29
• [Presentation] 糖尿病や肥満とコレステロール合成マーカーおよび吸収マーカーの関連についての検討 (2011)
  • Author(s): 藍真澄、朝永修、小川智也、田中明、山崎瑞樹、土井里紗、田中次郎、岡崎正巳、伊藤顕彦、薄田康広、竹井義純、梅本朋幸、畑明広、諸星政治、村川祐一、丹羽明、羽鳥浩、谷口善郎、森谷茂樹、本間聡起、吉田雅幸
  • Organizer: 第54回日本糖尿病学会
  • Place of Presentation: 札幌
  • Year and Date: 20110519-21
• [Presentation] 若年女性の卵黄負荷による血清リポたんぱく質の変動 (2011)
  • Author(s): 堀口さやか、土門茉莉奈、臼井みさ紀、萩原千絵、広渡祐史、伊藤康樹、田中明、川端輝江
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: 東京
  • Year and Date: 20110513-15
• [Presentation] 肥満・メタボリックシンドロームに対する栄養戦略 (2011)
  • Author(s): 田中明
  • Organizer: 第33回日本臨床栄養学会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-10-29
• [Presentation] 「解剖学・生理学、生化学、基礎栄養学」、シンポジウム管理栄養士養成過程における教育のあり方に関する検討会第1回報告 (2011)
  • Author(s): 田中明
  • Organizer: 日本栄養改善学会
  • Place of Presentation: 広島
  • Year and Date: 2011-09-08
• [Presentation] レムナントリポ蛋白の動脈硬化における意義 (2011)
  • Author(s): 田中明
  • Organizer: 第20回日本脂質栄養学会
  • Place of Presentation: 坂戸
  • Year and Date: 2011-09-03
• [Presentation] 「コレステロールを再考する」パネルディスカッションコレステロールを再考する (2011)
  • Author(s): 田中明
  • Organizer: 第20回日本脂質栄養学会
  • Place of Presentation: 坂戸
  • Year and Date: 2011-09-02
• [Presentation] Remnant-TG as a therapeutic target (2011)
  • Author(s): Nakajima K, Tanaka A
  • Organizer: The XVII International Symposium on drug affecting lipid metabolism(DARM)
  • Place of Presentation: Qatar
  • Year and Date: 2011-02-01
• [Presentation] Diacylglycerol Oil-Rich Diet Induces Lower Glucose-Dependent Insulinotropic Polypeptide and Insulin responses in Obese Men (2010)
  • Author(s): Ai M, Tanaka A, Takeshita M, Hari S, Katsuragi Y
  • Organizer: 第42回日本動脈硬化学会総会
  • Place of Presentation: 岐阜
  • Year and Date: 20100715-16
• [Presentation] Determination of remnant-like lipoprotein particle-triglyceride(RLP-TG) in postprandial hyperlipidemic plasma (2010)
  • Author(s): Nakano T, Okazaki M, Tanaka A, Nakajima K
  • Organizer: 第42回日本動脈硬化学会総会
  • Place of Presentation: 岐阜
  • Year and Date: 20100715-16
• [Presentation] 栄養相談時にかける時間による栄養相談効果の差異 (2010)
  • Author(s): 蒲池桂子、黒澤真奈、露崎可奈、春日千加子、榊玲里、林昌子、由井美和、帰山由佳、新出真理、小川万紀子、下門顕太郎、田中明
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 20100527-29
• [Presentation] 医科栄養学教育を考える～栄養クリニック、管理栄養士養成の立場から～シンポジウム「医科栄養学教育を考える」 (2010)
  • Author(s): 田中明
  • Organizer: 日本臨床栄養協会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-08-28
• [Presentation] Diacylglycerol oil-rich diet induces lower glucose-dependent insulinotropic polypeptide and insulin responses in obese men (2009)
  • Author(s): Ai M, Tanaka A, Takeshita M, Hari S, Katsuragi Y
  • Organizer: 82^<nd> AHA meeting
  • Place of Presentation: Orland, FL, USA
  • Year and Date: 20091115-19
• [Presentation] 「医師の視点からみた管理栄養士・栄養士教育の展望」、シンポジウム「管理栄養士教育モデルコアカリキュラムの導入と今後の展望」 (2009)
  • Author(s): 田中明
  • Organizer: 第56回日本栄養改善学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20090902-04
• [Presentation] The effect of diet intervention on remnant lipoproteins in obese women (2009)
  • Author(s): Kaeriyama Y, Ai M, Ysuyuzaki K, Jayashi M, Kurosawa M, Sakaki R, Hayashi Y, Kasuga C, Morizono H, Yurimoto M, Kamachi K, Tanaka A, kagawa Y
  • Organizer: 第41回日本動脈硬化学会総会
  • Place of Presentation: 下関
  • Year and Date: 20090718-19
• [Presentation] 適切な指導による減量は骨密度を増加させる (2009)
  • Author(s): 黒澤真奈、藍真澄、露崎可菜、林裕子、林昌子、塚田愛、春日千加子、榊玲里、森園浩子、百合本真弓、蒲池桂子、田中明、香川靖雄
  • Organizer: 第2回日本肥満症治療学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20090710-11
• [Presentation] Fasting and Postprandial Apolipoprotein B-48 Levels in Normal, Obese, and Hyperlipidemic Sbjects (2009)
  • Author(s): Otokosawa S, Ai M, Diffenderfer MR, Tanaka A, Lamon-Fava S, Schefer E
  • Organizer: The Xvth International Simposium on Atherosclerosis
  • Place of Presentation: Boston
  • Year and Date: 20090614-18
• [Presentation] A simple and precise method for measuring HDL-cholesterol subfractions, and its clinical significance (2009)
  • Author(s): Hirano T, Koba S, Tanaka A, Taira T, Ito Y
  • Organizer: The Xvth International Simposium on Atherosclerosis
  • Place of Presentation: Boston
  • Year and Date: 20090614-18
• [Presentation] The presence of postprandial remnant lipoproteins in the fasting plasma with TG levels below 150mg/ dL
  • Author(s): Nakajima K, Nakano T, Tokita Y, Nagamine T, Yasuzuka S, Shimomura Y, Tanaka A
  • Organizer: American Association of Clinical Chemistry
  • Place of Presentation: Atlanta, GA, USA
  • Year and Date: 00000724-27