2011 Fiscal Year Final Research Report
Changes of Transcriptome and DNA methylation in P19 neurons exposed to Bisphenol A
| Project/Area Number |
21510072
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YAOI Takeshi 京都府立医科大学, 医学研究科, 助教 (40311914)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 内分泌かく乱物 / エピジェネティクス / 発生・分化 / 脳・神経 / 環境化学物質 / 環境エピジェネティクス |
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| Research Abstract |
It was revealed that the exposure to one of the "non-toxic" BPA metabolites could elicit both epigenetic mutations and perturbation of transcriptome in mouse P19 neurons. The differentially expressed genes were highly significantly enriched for the BPA-responsive gene set. mRNA expression of most of them was also altered in the fetal forebrain maternally exposed to BPA. These data suggested that the metabolite was one of the potent bioactive forms of BPA molecule in the BPA-exposed fetal brain.
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[Journal Article] Organ distribution of quantum dots after intraperitoneal administration, with special reference to area-specific distribution in the brain2010
Author(s)
Kato S, Itoh K, Yaoi T, Tozawa T, Yoshikawa Y, Yasui H, Kanamura N, Hoshino A, Manabe N, Yamamoto K, Fushiki S
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Journal Title
Nanotechnology
Volume: 21(33)
Pages: 335103
DOI
Peer Reviewed
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