2011 Fiscal Year Final Research Report
Chemical Properties of Pt(II) Complexes Effective for Cisplatin Resistance Cancer and Its Application to Anticancer Drugs
| Project/Area Number |
21550058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
ODANI Akira 金沢大学, 薬学系, 教授 (60143913)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 白金抗がん剤 / シスプラチン / 耐性 / 腎毒性 / イオン / プロテアソーム活性阻害 |
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| Research Abstract |
The weak points in cisplatin type Pt(II) anticancer drugs are(1) lower activity for cisplatin resistance cancer,(2) high nephrotoxicity, however, these points were solved by the introduction of the ionic form to Pt(II) complexes. The cationic Pt(II) complexes involving aromatic ring stacking, which was shown in cisplatin coordinated DNA-HMG protein adduct, showed the proteasome inhibition as a new anticancer mechanism. Both the cationic and the anionic Pt(II) complexes exhibited the excellent anticancer effect and are considered to be possible to develop the clinical anticancer drugs.
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