2011 Fiscal Year Final Research Report
Synthesis and characterization of composite metal complexes aiming at regulations of genetic information
| Project/Area Number |
21550070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Chuo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Yusuke 中央大学, 理工学部, 助教 (80433019)
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| Project Period (FY) |
2009 – 2011
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| Keywords | DNA / 複合金属錯体 / 多核錯体 / DNAコンジュゲート / 抗癌活性 / 一塩基多形 |
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| Research Abstract |
We have synthesized various mixed ligand and multinuclear metal complexes and analyzed the DNA binding structures、evaluating the DNA binding affinity and the cleavage activity. The results indicated that the composite metal complexes strengthened efficiently the interaction with DNA and enhanced the cleavage activity. In addition、some of the complexes have been found to show a new type of anticancer activity. We have also synthesized new DNA metal complex conjugates and succeeded in developing an efficient technique for the detection of DNA SNPs by making use of protein splicing reactions.
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