2011 Fiscal Year Final Research Report
Developments of selective detection methods of oligosaccharides bound to receptor molecule
| Project/Area Number |
21550092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Meisei University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Etsuro 東京大学, 大学院・農学生命科学研究科, 教授 (10130303)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生物学的分析 / 高精度選択的分析 |
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| Research Abstract |
Various new methods to detect interactions of the protein-ligandcomplex have been developed. Although sample solutions containing 100% D_2O weregenerally used in the previous studies, new methods, which can handle 95% H_2O and 5% D_2O, were required on the point of easy sample preparation with avoiding sample loss. Effective and sensitive detection of ligand signals, resonating close to water, was alsoperformed in this research project. These methods are expected to be useful in thechemical and pharmaceutical fields.
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