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2011 Fiscal Year Final Research Report

Construction and functionalization of molecular containers composed of peptidemimetic chiral bowls having C3-symmetry

Research Project

  • PDF
Project/Area Number 21550129
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional materials chemistry
Research InstitutionChiba University

Principal Investigator

AKAZOME Motohiro  千葉大学, 大学院・工学研究科, 准教授 (10261934)

Project Period (FY) 2009 – 2011
Keywords超分子化学 / ホスト-ゲスト化学 / ボウル型化合物
Research Abstract

We synthesized bowl-shaped cyclic peptidomimetic s from amino acids and elucidated their conformation. These cyclic peptides as new host compounds were examined their guest binding ability. After introduction of aggregable functional group on the rim of the bowl-shaped cyclic peptide, the aggregation of the bowls was observed by NMR spectra with varying concentration of the bowl.

  • Research Products

    (11 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results)

  • [Journal Article] Synthesis andC2-Symmetric Structure of a Cyclotetrapeptide Composed of Anthranilic Acidand Leucine2011

    • Author(s)
      Motohiro Akazome, Masashi Enzu, Koji Takagi, Shoji Matsumoto
    • Journal Title

      Chirality

      Volume: 23 Pages: 568-573

    • Peer Reviewed
  • [Journal Article] Inclusion of aliphatic alcohols in pockets of (S)-threonyl-(S)-phenylglycine using grinding2011

    • Author(s)
      Motohiro Akazome, Shusaku Toma, Tatsunori Horiguchi, Ken Megumi, Shoji Matsumoto
    • Journal Title

      method

      Volume: 67 Pages: 2844-2848

    • Peer Reviewed
  • [Journal Article] Synthesis of a Chiral C_3 -Symmetric Bowl-Shaped Cyclohexapeptide Composed of Anthranilic Acid and Leucine2011

    • Author(s)
      Motohiro Akazome, Masashi Enzu, Yohei Goto, Shoji Matsumoto
    • Journal Title

      Heterocycles

      Volume: 82 Pages: 1645-1656

    • Peer Reviewed
  • [Journal Article] Predominant (S)-Enantioselective Inclusion of Aryl Methyl Sulfoxides by(S)-Isoleucyl-(S)-phenylglycines2010

    • Author(s)
      Motohiro Akazome, Ai Doba, Shoji Matsumoto, Katsuyuki Ogura
    • Journal Title

      TheJournal of Organic Chemistry

      Volume: 65 Pages: 660-665

    • Peer Reviewed
  • [Journal Article] A cyclictrimer of 2-(2-aminophenoxy) propionic acid with a bowl-shaped structure2009

    • Author(s)
      Motohiro Akazome, Junpei Sukegawa, Yohei Goto, Shoji Matsumoto
    • Journal Title

      Tetrahedron Letters

      Volume: 50 Pages: 5382-5385

    • Peer Reviewed
  • [Presentation] Cyclic Tripeptides of 2-(Aminophenoxy) alkanoic Acids2011

    • Author(s)
      Motohiro Akazome
    • Organizer
      the Bowl-shaped Structure and Molecular Recognition
    • Place of Presentation
      Bangkok, (Thailand)
    • Year and Date
      2011-09-08
  • [Presentation] Binding of Quaternary Ammonium Compounds to Bowl-shaped Tripeptides of2-(3-Aminophenoxy) alkanoic acids2011

    • Author(s)
      Motohiro Akazome, Norihiro Hamada, Koji Takagi, Shoji Matsumoto
    • Organizer
      23rdInternational Symposium on Chiral Discrimination (Chirality 2011)
    • Place of Presentation
      University of Liverpool (UK)
    • Year and Date
      2011-07-11
  • [Presentation] ジペプチドやアミノ酸塩の有機結晶を用いる包接現象と不斉認識2010

    • Author(s)
      赤染元浩
    • Organizer
      日本化学会第4回関東支部大会
    • Year and Date
      2010-08-30
  • [Presentation] Chiral Bowl-Shaped Structure of Cyclic Peptides Composed of Anthranilic Acid and Leucine2010

    • Author(s)
      Motohiro Akazome, Masashi Enzu, Yohei Goto, Shoji Matsumoto
    • Organizer
      22ndInternational Symposium on Chirality
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2010-07-14
  • [Presentation] アントラニル酸とロイシンからなる環状ペプチドの合成と構造2010

    • Author(s)
      赤染元浩, 遠津正, 松本祥治
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      近畿大学(東大阪市)
    • Year and Date
      2010-03-27
  • [Presentation] 2-(2-アミノフェノキシ)アルカン酸からなるオリゴペプチドのヘリックスならびにボウル構造2009

    • Author(s)
      赤染元浩, 後藤洋平, 助川順平, 松本祥治
    • Organizer
      第5回ホスト-ゲスト化学シンポジウム
    • Place of Presentation
      宇都宮大学(宇都宮市)
    • Year and Date
      2009-05-30

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Published: 2013-07-31  

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