2011 Fiscal Year Final Research Report
Studies of the functional roles of amphibian skin antimicrobial peptides as the first barrier against infection by environmental microorganisms.
| Project/Area Number |
21570068
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphology/Structure
|
|---|
| Research Institution | Toho University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KIKUYAMA Sakae 早稲田大学, 教育・総合学術院, 名誉教授 (20063638)
KOBAYASHI Tetsuya 埼玉大学, 大学院・理工学研究科, 教授 (00195794)
HASUNUMA Itaru 東邦大学, 理学部, 講師 (40434261)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 比較内分泌 / 抗菌ペプチド / 免疫内分泌 / 生体防御 / 両生類 / 抗菌性ヒストン |
|---|
| Research Abstract |
We have cloned and characterized cDNAs encoding multiple antimicrobial peptide precursors from total RNA samples prepared from the skin and some extradermal tissues such as brain and the Harderian gland of the Japanese Ranid frog species. The synthetic replicates of some of these peptides showed anti-tumor cell activities and/or mast cell-stimulating activities as well as antimicrobial activities. We investigated anti-Escherichia coli activities of the Lys-rich histone H2B and Arg-rich histones H3 and H4 as antimicrobial agents and showed that the mode of their antimicrobial actions depended on their basic amino acid residue contents.
|
Research Products
(28 results)
