2011 Fiscal Year Final Research Report
Control of estrogen receptor expression by serotonergic neurons in the raphe nuclei
| Project/Area Number |
21570070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Waseda University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経内分泌 |
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| Research Abstract |
Change of estrogen receptor α(ERα) in the neurons of the brain is an important to control reproductions such as ovulatory cycle in rats. In this experiment, it has been shown that degree of down-regulation of ERα by estrogen is different among regions of the brain or sexes, and ERα plays an important role in sexual differentiation of the brain functions. Furthermore, expression of ERα is influenced by serotonergic neurons. Serotonergic neurons itself have a sex difference and have a role to prevent irregular ovulatory cycle induced by a physical stress.
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