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2011 Fiscal Year Final Research Report

Investigation on the molecular mechanism modulating EGFR signal transduction via the membrane-associated sialidase

Research Project

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Project/Area Number 21570122
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Structural biochemistry
Research Institution地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所) (2011)
Miyagi Cancer Center Research Institute (2009-2010)

Principal Investigator

YAMAGUCHI Kazunori  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), 発がん制御研究部, 上席主任研究員 (80373215)

Co-Investigator(Kenkyū-buntansha) TATENO Hiroo  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), 病理部, 部長 (70004744)
Project Period (FY) 2009 – 2011
Keywords糖質 / シグナル伝達
Research Abstract

The membrane-associated sialidase NEU3, a kind of glycolytic enzyme, localizes at cell membrane and promotes tumor formation through activation of EGFR. We previously showed that interaction between NEU3 and EGFR plays role in the activation. In this study, we investigated an involvement of NEU3 in colon tumor formation by using Neu3 knock out mice. We also analyzed interaction between NEU3 and EGFR at molecular level

  • Research Products

    (21 results)

All 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (11 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Regulation of Sialyl Lewis Antigen Expression in Colon Cancer Cells by Sialidase NEU42011

    • Author(s)
      Shiozaki, K., Yamaguchi, K., Takahashi, K., Moriya, S., Miyagi, T.
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 21052-21061

    • Peer Reviewed
  • [Journal Article] Regulation of plasma-membrane-associated sialidase NEU3 gene by Sp1/Sp3 transcription factors2010

    • Author(s)
      Yamaguchi, K., Koseki, K., Shiozaki, M., Shimada, Y., Wada, T., Miyagi, T.
    • Journal Title

      Biochem. J

      Volume: 430 Pages: 107-117

    • Peer Reviewed
  • [Journal Article] A crucial role of sialidase Neu1 in hyaluronan receptor function of CD44 in T helper type 2-mediated airway inflammation of murine acute asthmatic model2010

    • Author(s)
      Katoh, S., Maeda, S., Fukuoka, H., Yamaguchi, K., Senda, S., Miyagi, T.(他3名、7番目)
    • Journal Title

      Clin. Exp. Immunol

      Volume: 161 Pages: 233-241

    • Peer Reviewed
  • [Journal Article] Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation2009

    • Author(s)
      Shiozaki, K., Koseki, K., Yamaguchi, K., Miyagi, T.(他2名、3番目)
    • Journal Title

      J. Biol. Chem

      Volume: 284 Pages: 21157-21164

    • Peer Reviewed
  • [Journal Article] Plasma membrane-associated sialidase(NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice2009

    • Author(s)
      Shiozaki, K., Yamaguchi, K., Sato, I., Miyagi, T.
    • Journal Title

      Cancer Sci

      Volume: 100 Pages: 588-594

    • Peer Reviewed
  • [Journal Article] Synthesis of All Possible Isomers Corresponding to the Proposed Structure of Montanacin E, and Their Antitumor Activity2009

    • Author(s)
      Takahashi, S., Takahashi, R., Hongo, Y., Koshino, H., Yamaguchi, K., Miyagi, T.
    • Journal Title

      J. Org. Chem

      Volume: 74 Pages: 6382-6385

    • Peer Reviewed
  • [Journal Article] Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin beta42009

    • Author(s)
      Uemura, T., Shiozaki, K., Yamaguchi, K., Miyazaki, S., Satomi, S., Kato, K., Sakuraba, H., Miyagi, T.
    • Journal Title

      Oncogene

      Volume: 28 Pages: 1218-1229

    • Peer Reviewed
  • [Journal Article] Plasma membrane-associated sialidase(NEU3) regulates progression of prostate cancer to androgen-independent growth through modulation of androgen receptor signaling

    • Author(s)
      Kawamura, S., Yamaguchi, K., Miyagi, T(他12名、4番目)
    • Journal Title

      Cell Death. Differ

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] シアリダーゼNEU3の異常亢進はEGFRシグナリング活性化を介してがんの進展に導く2011

    • Author(s)
      宮城妙子,高橋耕太,和田正,山口壹範,塩崎一弘,細野雅祐,仁田一雄
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] 形質膜シアリダーゼ(NEU3)は癌幹細胞性を制御する2011

    • Author(s)
      高橋耕太,和田正,山口壹範,細野雅祐,仁田一雄,宮城妙子
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] シアリダーゼNEU3はARシグナリング修飾を介して前立腺癌のアンドロゲン非依存性増殖への進展を制御する2011

    • Author(s)
      佐藤郁朗,川村貞文,栃木達夫,和田正,山口壹範,高橋耕太,宮城妙子
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] 形質膜シアリダーゼNEU3の膜トポロジーに関する研究2011

    • Author(s)
      秦敬子,和田正,橋井則貴,川崎ナナ,塩崎一弘,山口壹範,高橋耕太,森谷節子,細野雅祐,仁田一雄,宮城妙子
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-21
  • [Presentation] メダカシアリダーゼNeu3のクローニングおよび性状解析2011

    • Author(s)
      塩崎一弘,竹下一輝,池田真子,小松正治,山田章二,山口壹範,宮城妙子
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-21
  • [Presentation] Plasma membrane-associated sialidase(NEU3) regulates progression of prostate cancer through modulation of androgen receptor signaling2011

    • Author(s)
      Kawamura S., Sato I., Wada T., Yamaguchi K., Moriya S., Miyagi T.
    • Organizer
      21st International Symposium on Glycoconjugates
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2011-08-21
  • [Presentation] シアリダーゼNeu4による神経接着分子NCAMポリシアル酸分解の制御2010

    • Author(s)
      高橋耕太,塩崎一弘,山口壹範,森谷節子,宮城妙子
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
  • [Presentation] シアリダーゼNEU3によるEGFRシグナリング活性化機構の解析2010

    • Author(s)
      秦敬子,和田正,山口壹範,高橋耕太,森谷節子,塩崎一弘,宮城妙子
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
  • [Presentation] Sialidase NEU4 attenuates E-selectin derived signaling in colon cancer cells2010

    • Author(s)
      Shiozaki, K., Yamaguchi, K., Takahashi, K., and Miyagi, T.
    • Organizer
      Sialoglyco meeting
    • Place of Presentation
      Potsdam, Germany
    • Year and Date
      2010-08-21
  • [Presentation] Activation of plasma membrane-associated sialidase NEU3 by phospholipid2010

    • Author(s)
      Shiozaki, K., Hata, K., Yamaguchi, K., and Miyagi, T.
    • Organizer
      The 28th Naito Conference on Glycan Expression and Regulation[I] Functions and Disease Mechanisms
    • Place of Presentation
      Hayama, Japan
    • Year and Date
      2010-07-27
  • [Presentation] シアリダーゼNEU3はフォスファチジン酸により活性化される2010

    • Author(s)
      塩崎一弘,山口壹範,宮城妙子
    • Organizer
      生理学研究所研究会糖鎖機能研究会
    • Place of Presentation
      岡崎
    • Year and Date
      2010-07-01
  • [Book] 生物機能モデルと新しいリソース・リサーチツール2011

    • Author(s)
      山口壹範、宮城妙子(分担執筆者)
    • Total Pages
      340-345
    • Publisher
      エル.アイ.シーシアリダーゼ
  • [Remarks]

    • URL

      http://www.cbt.med.tohoku.ac.jp/member2.html

URL: 

Published: 2013-07-31  

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