2011 Fiscal Year Final Research Report
Functional analysis of UBL-UBA proteins in the ubiquitin-proteasome pathway.
| Project/Area Number |
21570140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yasushi 岡山大学, 大学院・自然科学研究科, 教授 (40091251)
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| Co-Investigator(Renkei-kenkyūsha) |
SEKIGUCHI Takeshi 九州大学, 大学院・医学研究院, 助教 (60187846)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞内タンパク質分解・ユビキチン / プロテアソーム |
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| Research Abstract |
Ubiquitin-dependent protein degradation regulates the recognition and delivery of degradable proteins in various cellular functions including the cell cycle. To understand a functional role of UBL-UBA protein, yeast protein Dsk2, which is involved in the delivery process of protein degradation, we identified the Dsk2-interacting proteasome subunits and its accessory factors and analyzed their cellular functions. In this study, as a result, we clarified the regulatory function of UBL-UBA protein in the delivery system of the ubiquitin-proteasome pathway.
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[Journal Article] Fub1p, a novel protein isolated by boundary screening, binds the proteasome complex2011
Author(s)
Hatanaka A, Chen B, Sun J-Q, Mano Y, Funakoshi M, Kobayashi H, Ju Y, Mizutani T, Shimyozu K, Nakayama J, Miyamoto K, Uchida H and Oki M.
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Journal Title
Genes Genet. Syst.
Volume: 86
Pages: 305-314
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