2011 Fiscal Year Final Research Report
Regulation of CD44-hyaluronan interaction by SHAP and its role in inflammation
| Project/Area Number |
21570147
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Aichi Medical University |
|---|
Principal Investigator |
ZHUO Lisheng 愛知医科大学, 医学部, 准教授 (00399031)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KIMATA Koji 愛知医科大学, 名誉教授 (10022641)
BABA Kenji 愛知医科大学, 医学部, 教授 (80211499)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 糖鎖生物学 |
|---|
| Research Abstract |
CD44and its ligand hyaluronan emerge as important adhesion molecules for leucocyte infiltration in inflammatory response. We have found that the serum protein SHAP binds covalently to hyaluronan and enhances the adhesion of CD44-positive cells to hyalurona. In this project, we reveal that SHAP plays significant roles in in vivo inflammatory responses by using SHAP-deficient mice. Depending on the affected organ and disease model, the role of SHAP varies, either being inflammatory(such as in acute liver injury model) or being anti-inflammatory(such as in airway hyper-responsiveness model and intracerebral hemorrhage model).
|
-
-
-
-
-
-
-
[Journal Article] Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice2009
Author(s)
Garantziotis S, Li Z, Potts EN, Kimata K, Zhuo L, Morgan DL, Savani RC, Noble PW, Foster WM, Schwartz DA, Hollingsworth JW
-
Journal Title
J Biol Chem
Volume: 284(17)
Pages: 11309-17
Peer Reviewed
-
-
-
-
-
-
-
-
[Presentation] Hyaluronan plays significant roles not only in maintenance of musculoskeletal systems but also in tumorigenecity of musculoskeletal malignant tumors2010
Author(s)
Nishida Y, Wasa J, Urakawa H, Arai E, Shinomura T, Zhuo L, Kimata K, Knudson W, Knudson C, Ishiguro N
Organizer
HA2010
Place of Presentation
Kyoto, Japan
Year and Date
20100600
-
-
-
-
-
-
-
-
-
-
-
-
-
-
