2011 Fiscal Year Final Research Report
The analysis of the regulation of PIKK by Tel2 family protein
| Project/Area Number |
21570186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Kwansei Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | DNA複製 / DNA損傷 / チェックポイント / 細胞応答 / PIKKキナーゼ |
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| Research Abstract |
To understand how Tel2 protein regulates the PIKK family proteins conserved among eukaryotes, we tried to isolate conditionally lethal tel2 mutants of fission yeast and analyzed. We found that Tel1^<ATM>/Rad3^<ATR> or Tor1/Tor2^<TOR> were not destabilized in tel2 mutants defective in Tel1^<ATM>/Rad3^<ATR> or Tor1/Tor2^<TOR> pathway, suggesting that Tel2 is not involved in the stability of PIKKs and has a novel function in the regulation of PIKKs.
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