2011 Fiscal Year Final Research Report
Genetic analysis of dopamine signaling that regulates avoidance behavior in the nematode C. elegans
| Project/Area Number |
21570187
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Molecular biology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
KIMURA Kotaro 大阪大学, 大学院・理学研究科, 特任准教授 (20370116)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 分子間相互作用 / 神経機能の可塑性 |
|---|
| Research Abstract |
Avoidance behavior of the nematode C. elegans to 2-nonanone is significantly enhanced, rather than reduced, after 1 hr-preexposure to the odor. In this project, we found that the D2-like dopamine receptor DOP-3 is required in a couple of interneurons RIC to regulate the enhancement to repulsive odor 2-nonanone in the animals. Our result may shed light on molecular mechanism of dopamine signaling that plays significant roles in regulating locomotion, emotion and learning in mammalian brain.
|
