2011 Fiscal Year Final Research Report
Mechanosensing system for regulating the cell morphology during cytokinesis
| Project/Area Number |
21570199
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UYEDA Taro バイオメディシナル情報研究センター, 副研究センター長 (90356551)
IWADATE Yoshiaki 山口大学, 大学院・医学系研究科, 准教授 (40298170)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞質分裂 / アクチン / ミオシン |
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| Research Abstract |
Cells always monitor their size and shape. The excess shape change, which may result in tearing the cell membrane, should be put back by a feedback mechanism. Such mechanism may guarantee the equal division of cell volume during cytokinesis. In this study, we found actin filaments act as a mechanosensor in Dictyostelium cells. Additionally, myosin and PTEN also participated this function. The defects of this mechanism induced abnormal cytokinesis.
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