2011 Fiscal Year Final Research Report
Molecular mechanism of crinophagy
| Project/Area Number |
21570206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Nagahama Institute of Bio-Science and Technology |
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Principal Investigator |
YAMAMOTO Akitsugu 長浜バイオ大学, バイオサイエンス学部, 教授 (30174775)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞性粘菌 / Dictyostelium discoideum / クリノファジー / PSV / リソソーム / エンドソーム / 電子顕微鏡 / プロテオミックス |
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| Research Abstract |
During dedifferentiation process of prespore cells of cellular slime mold Dictyostelium discoideum, it was revealed by electron microscopic observation that PSVs ; secretory granules specifically present in prespore cells sre degraded simultaneously by crinophagy in which PSVs are directly fused with lysosomes. In crinophagy of PSVs, it was found that PSVs fuse with endosomes as well as with lysosomes, suggesting that endosomes are deeply concerned with crinophagy.
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