2013 Fiscal Year Final Research Report
Investigation of mechanism of epithelial invagination using the 3D cell model
| Project/Area Number |
21570234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Hyogo University
Kobe University |
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Principal Investigator |
HONDA Hisao 神戸大学, 医学研究科, 学術推進研究員 (10289118)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Keywords | invagination / cell model / vertex dynamics / morphogenesis |
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| Research Abstract |
The process of morphogenesis of multi-cellular organisms can be expressed as "Genes-Cells-Shape". To elucidate the detailed process based on actual substances, I studied a latter half of the process from Cells to Shape using a mathematical cell model. A computer simulation was performed of an epithelial invagination of the trachea formation of Drosophila, referring to actual observations. The simulation of the invagination was succeeded based several assumptions of cell behaviors. However, one of the assumptions, cell migration toward the embryo inside is arguable. On the other hand, I studied a polygonal cellular pattern of invagination in the neural tube formation. Here, anisotropic localization of the planar cell polarity gene, celsr was elucidated to cause anisotropic localization of myosin molecules that generates morphogenetic force. Then, one of the routes from genes to shape was established.
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[Presentation] Three-dimensional cell model for tissue morphogenesis2013
Author(s)
H. Honda
Organizer
Workshop "Computational modeling of regenerative medicine and cellular patern formation", 35th Annual International Conference of the IEEE Engineering in Medicin and Biology Society (EMSC)
Place of Presentation
International Convention Center in Osaka
Year and Date
2013-07-03
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