2011 Fiscal Year Final Research Report
The diversity of Plasmodium SERA gene family : Adaptation of parasitism and host range
| Project/Area Number |
21570238
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Osaka University |
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Principal Investigator |
ARISUE Nobuko 大阪大学, 微生物病研究所, 助教 (00242339)
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| Co-Investigator(Kenkyū-buntansha) |
TOUGAN Takahiro 大阪大学, 微生物病研究所, 助教 (20379093)
HORII Toshihiro 大阪大学, 微生物病研究所, 教授 (80142305)
YAGI Masanori 大阪大学, 微生物病研究所, 特任研究員 (60452463)
AOSHI Taiki 大阪大学, 微生物病研究所, 特任助教 (10324344)
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| Co-Investigator(Renkei-kenkyūsha) |
TANABE Kazuyuki 大阪大学, 微生物病研究所, 招聘教授 (40047410)
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| Project Period (FY) |
2009 – 2011
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| Keywords | マラリア原虫 / 遺伝子ファミリー / 遺伝子多型 / SERA / 宿主 |
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| Research Abstract |
Transcriptional profiles and sequence diversities were analyzed using SERA genes of malaria parasites from a variety of different vertebrate hosts. As a result, we found that the repertories of SERA genes showing abundant expression and essential for parasite survival were different between primate and rodent parasites. In addition, primate parasites when compared to rodent parasites have larger number of SERA genes and positive selections were detected in the several SERA genes in primate parasites. These findings suggest that SERA genes have acquired multiple functions relevant to the parasite extension of host range.
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[Journal Article] Geographic differentiation of polymorphismin the Plasmodium falciparum malariavaccine candidate gene SERA52012
Author(s)
Kazuyuki Tanabe, Nobuko Arisue, NirianneM. Q. Palacpac, Masanori Yagi, TakahiroTougan, Hajime Honma, Marcelo U. Ferreira, Anna Farnert, Anders Bjorkman, Akira Kaneko, Masatoshi Nakamura, KenjiHirayama, Toshihiro Mita, Toshihiro Horii
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Journal Title
Vaccine
Volume: 30
Pages: 1583-1593
Peer Reviewed
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[Journal Article] Serologic markers in relation to parasiteexposure history help to estimatetransmission dynamics of Plasmodium vivax2011
Author(s)
Fadile Yildiz Zeyrek, Nirianne Palacpac, Fehmi Yuksel, Masanori Yagi, Kaori Honjo, Yukiko Fujita, Nobuko Arisue, Satoru Takeo, Kazuyuki Tanabe, Toshihiro Horii, TakafumiTsuboi, Ken J. Ishii, Cevayir Coban
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Journal Title
PLoS One
Volume: 6
Pages: e28126
Peer Reviewed
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[Journal Article] Lineage-specific positive selection at themerozoite surface protein 1(msp1) locus ofPlasmodium vivax and related simianmalaria parasites2010
Author(s)
Hiromi Sawai, Hiroto Otani, Nobuko Arisue, Nirianne Palacpac, Leonardo de Oliveira Martins, Sisira Pathirana, ShiromaHandunnetti, Satoru Kawai, Hirohisa Kishino, Toshihiro Horii, Kazuyuki Tanabe
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Journal Title
BMC Evol.Biol
Volume: 10
Pages: 52
Peer Reviewed
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