2011 Fiscal Year Final Research Report
Analysis of the physiological significance of GPI flippase and synthesis
| Project/Area Number |
21580094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Hiroshima University |
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Principal Investigator |
FUNATO Kouichi 広島大学, 大学院・生物圏科学研究科, 准教授 (30379854)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 微生物機能 / 糖脂質 / 生体膜 / 細胞機能制御 |
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| Research Abstract |
Glycosylphosphatidylinositol(GPI) is a complex glycolipid that anchors proteins to the plasma membrane. In this study, using a deletion mutant of ARV1 gene that encodes a putative flippase required for the transport of a GPI intermediate to the ER lumen and other mutants defective in GPI synthesis, we found that GPI synthesis regulates aging and cell death in yeast, and the cell death is largely concerned with structure and function of telomere.
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