2011 Fiscal Year Final Research Report
Studies on gastrointestinal mucosa-maintaining factors produced during digestion of foods
| Project/Area Number |
21580141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TANAKA Tamotsu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (90258301)
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| Co-Investigator(Kenkyū-buntansha) |
TOKUMURA Akira 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00035560)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 食品 / 消化管粘膜保護 / ホスファチジン酸 / 抗潰瘍 / リン脂質 / セラミド1-リン酸 |
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| Research Abstract |
Studies on gastrointestinal mucosa-maintaining factors in foods and digested foods were conducted. We found that phosphatidic acid(PA), a characteristic phospholipid in plant foodstuffs, effectively ameliorates aspirin-induced stomach ulcer. The lysophosphatidic acid produced by the hydrolysis of the PA was involved in the ulcer-ameliorating activity of PA. We also identified phytoceramide-1-phsphate as a novel sphingophospholipid with anti-apoptotic activity in cabbage leaves.
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