2011 Fiscal Year Final Research Report
Studies on the protective effect of acetate on metabolic syndrome
| Project/Area Number |
21580150
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Okayama Prefectural University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMOTO Masumi 岡山県立大学, 保健福祉学部, 教授 (40108866)
TAKAHASHI Yoshitaka 岡山県立大学, 保健福祉学部, 教授 (10236333)
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| Project Period (FY) |
2009 – 2011
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| Keywords | メタボリックシンドローム / 脂質代謝 / 食品 / 酢酸 / 細胞・組織 |
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| Research Abstract |
Previously, we reported that oral administrated acetate contributed to suppression of lipogenesis in the liver, to the reduction of lipid accumulation in adipose tissue, and to the improvement of glucose tolerance of Otsuka Long-Evans Tokushima Fatty(OLETF) rats. Acetate has a potential for prevention of metabolic syndrome. In this study, we investigated the effect of acetate on skeletal muscle and adipose tissue. It was shown that acetate stimulated expressions of myoblobin and GLUT4 via activation of AMP-activated protein kinase(AMPK) and it enhanced fatty acid metabolism and glucose uptake in skeletal muscle.
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[Journal Article] Effects of acetate on lipid metabolism in muscle and adipose tissue of type 2 diabetic Otsuka Long-Evans Tokushima Fatty(OLETF) rats2009
Author(s)
Yamashita, H., Maruta, H., Jozuka, M., Kimura, R., Iwabuchi, H., Yamato, M., Saito, T., Fujisawa, K., Takahashi, Y., Kimoto, M., Hiemori, M., Tsuji, H.
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Journal Title
Biosci. Biotechnol. Biochem
Volume: 73(3)
Pages: 570-576
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