2011 Fiscal Year Final Research Report
Destruction of niche and target-cells in autoimmune diseases by effector cells and molecules
| Project/Area Number |
21580362
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 自己免疫疾患 / 1型糖尿病 / 全身性エリテマトーデス / シェーグレン症候群 / モデル / アレルギー性喘息 / 病理発生 / Niche |
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| Research Abstract |
One might expect that effector cells(and/ or effector molecules) encounter firstly micro-environmental component(niche) before the destruction of target-cells in autoimmune diseases. However, there is a little attention of destruction of niche morphologically and functionally in the pathogenesis in immune diseases. During the analysis of autoimmune diseases the importance of niche concept in the pathogenesis of autoimmune diseases was clarified.
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