2011 Fiscal Year Final Research Report
The role of P2X receptor in overactive bladder and application of drugs targeting the receptor
| Project/Area Number |
21580365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | University of Miyazaki (2009, 2011)
Azabu University (2010) |
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Principal Investigator |
ITO Katsuaki 宮崎大学, 農学部, 名誉教授 (70136795)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Kaoru 南九州大学, 健康栄養学部, 教授 (70341633)
ASAI Fumitoshi 麻布大学, 獣医学部, 教授 (00511677)
ANO Hitohshi 宮崎大学, 農学部, 助教 (50372800)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 薬理 / 獣医 / 頻尿 / 膀胱痛 / P2X受容体 / TRPV1受容体 / ATP / 尿道 |
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| Research Abstract |
We examined the involvement of ATP receptor P2X_3 and vanilloid receptor TRPV1 in frequent voiding and pain accompanied with voiding in 4 models of frequent micturition of rats. Major findings are that pain during micturition increases the frequency of voiding and that the involvement of P2X_3 or TRPV1 varies depending of the type of micturition. Therefore, a drug targeting frequent voiding has to be determined depending on the pathogenesis of overactive bladder.
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