2011 Fiscal Year Final Research Report
Investigation of pathophysiologic mechanisms of acute cardiogenic shock by necrotizing toxins from gas gangrene bacilli.
| Project/Area Number |
21580379
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOZAKI Shunji 大阪府立大学, 生命環境科学研究科, 教授 (10109895)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 悪性水腫 / クロストリジウム / 細胞壊死毒素 / 心臓 / 心不全 / セプチカム |
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| Research Abstract |
Contraction of cultured cardiomyocytes from rat fetus heart ventricles have been stopped by pore formation of alpha-toxin on cell membranes. It was suggested that decrease of ATP productions and desiccation of ATP in cardiomyocytes have been caused by mitochondrial myopathy from Ca^<2+> excess in cytoplasm. It has been clear that tryptophan of 338th and 342th, hydrophobic amino acids of 340th and negative charged amino acids of 339th play an important roles in cell binding and cytotoxic activities of alpha-toxin.
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