2011 Fiscal Year Final Research Report
Synthetic Studies on Biologically Active Natural Products Aiming at Developing Novel Molecular-Targeted Agents
| Project/Area Number |
21590018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
KATOH Tadashi 東北薬科大学, 薬学部, 教授 (50382669)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Kazuhiro 東北薬科大学, 薬学部, 講師 (10382673)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 合成化学 / 抗がん剤 / 免疫抑制剤 / 創薬化学 / TAN-1813 / スピルコスタチン類 / FK228 |
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| Research Abstract |
The synthesis of the decalin and succinimide portions of the p21^<ras> farnecyltransferase inhibitor TAN-1813(antitumor substance) were efficiently achieved. In additions, two novel spiruchostatin analogs, spiruchostatin C and D(histone deacetylase inhibitors as molecular-targeted anticancer agents) were accomplished. Their biological evaluation revealed that spiruchostatins C and D are promising candidates for the development of novel anticancer agents.
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[Journal Article] Total Synthesis of the Bicyclic Depsipeptide HDAC Inhibitors Spiruchostatins A and B, 5''-epi-Spiruchostatin B, FK228(FR901228) and Preliminary Evaluation of Their Biological Activity2009
Author(s)
Koichi Narita, Takuya Kikuchi, Kazuhiro Watanabe, Toshiya Takizawa, Takamasa Oguchi, Kyosuke Kudo, Keisuke Matsuhara, Hideki Abe, Takao Yamori, Minoru Yoshida, Tadashi Katoh
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Journal Title
Chem. Eur. J.
Volume: 15巻
Pages: 11174-11186
DOI
Peer Reviewed
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