2011 Fiscal Year Final Research Report
Analysis of GPCR signaling in cortical development using the functional antibody
| Project/Area Number |
21590094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
MIZUNO Norikazu 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (90212232)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経科学 / 脳・神経 / 薬学 |
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| Research Abstract |
Using the functional antibodies against the neural progenitor cell-specific G protein coupled receptors(GPCRs), we investigated the function and the signal transduction of these GPCRs in cortical development. We elucidated that Gs-PKA signaling regulated the phosphorylation of doublecortin that induced the lamellipodium formation and neural progenitor cell migration, while Gq and G12/13 signals inhibited the migration.
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