2011 Fiscal Year Final Research Report
Synthesis of Novel Nucleoside Derivatives Applicable to Nucleic Acids Medicine
| Project/Area Number |
21590119
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | ヌクレオシド / 抗HIV活性 / 光延反応 / Pummerer反応 / イソヌクレオシド / 炭素環ヌクレオシド |
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| Research Abstract |
To develop nucleoside derivatives applicable to nucleic acids medicine with high affinity and stability and to search new anti-HIV agents, we designed and synthesized novel nucleoside derivatives. The target compounds were nucleosides having 2, 6-dioxabicyclo[3.2.0] heptane, dihydropyran and dihydrothiopyran derivatives as pseudosugar moieties. Among the compounds synthesized, dihydrothiopyranylcytosine showed significant anti-HIV activity.
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