2011 Fiscal Year Final Research Report
The inhibitory effect of aryl hydrocarbon receptor on spermatogenesis in vivo
| Project/Area Number |
21590140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
KIZU Ryoichi 同志社女子大学, 薬学部, 教授 (80143915)
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| Co-Investigator(Kenkyū-buntansha) |
SANADA Noriko 同志社女子大学, 薬学部, 助教 (60411089)
GOTOH Yuka 同志社女子大学, 薬学部, 助手 (90509259)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 内分泌撹乱物質 / アリル炭化水素受容体 / 多環芳香族炭化水素 / 精子産生機能 |
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| Research Abstract |
In this study, we investigated the mechanism for the inhibitory effect of AhR agonist(BaP) on spermatogenesis in vivo. BaP showed high AhR agonist activity and weak inhibitory effect on spermatogenesis in vivo analysis. The inhibitory effect of BaP on spermatogenesis was abolished by co-treatment with an AhR antagonist, a-naphthoflavone. These results suggest that AhR is involved in the inhibition of spermatogenesis by BaP.
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