Study on health risk assessment of chlorinated polycyclic aromatic hydrocarbons

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590147
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental pharmacy
• Research Institution: National Institute of Health Sciences
• Principal Investigator: NISHIMURA Tetsuji 国立医薬品食品衛生研究所, 生活衛生化学部, 部長 (20156110)
• Co-Investigator(Renkei-kenkyūsha): SUGIMOTO Naoki (50300918) ; SHIMIZU Kumiko
• Project Period (FY): 2009 – 2011
• Keywords: 多環芳香族炭化水素 / B[a] P / 塩素置換体 / 遺伝毒性 / Ah受容体 / 発生期

Research Abstract

The standards of chlorinated and bromated benzo[a] pyrenes were produced by chemical modification. After purification, the purities of these compounds were 94.6% of mono-chlorinated B[a] P replaced on 6 position, 97.2% of mono-bromated B[a] P replaced on 6 position, 94.6% of di-chlorinated B[a] P mixtures replaced 6, 11-and 6, 13-positions. These halogenated B[a] Ps showed weak toxicities on the cells and mutagenecities under the condition of metabolic activation. However, there were results of indicating the possibility of adverse effects on the nerve development process. The abundance was very little.

Research Products

• [Presentation] Generation and toxicities of halogenated benzo[a] pyrene (2011)
  • Author(s): Nishimura, T., Shimizu, K., Kubota, R., Kobayashi, N., Tahara, M., Obama, T., Hirose, A., Sugimoto, N.
  • Organizer: The 31st International Symposium on Halogenated Persistent Organic Pollutants
  • Place of Presentation: Brussels, Belgium
  • Year and Date: 2011-08-23
• [Presentation] 浄水工程を想定した生活関連化学物質の処理性評価 (2010)
  • Author(s): 久保田領志,田原麻衣子,清水久美子,杉本直樹,西村哲治
  • Organizer: 第47回全国衛生化学技術協議会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-12
• [Presentation] qNMRに基づく有機化合物の微量分析の検討 (2010)
  • Author(s): 杉本直樹,田原麻衣子,多田敦子,久保田領志,清水久美子,山崎壮,河村葉子,合田幸広,西村哲治
  • Organizer: 第47回全国衛生化学技術協議会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-12
• [Presentation] ベンゾ[a]ピレンハロゲン置換体の変異原性と細胞毒性 (2009)
  • Author(s): 西村哲治,清水久美子,久保田領志,小濱とも子,田原麻衣子,杉本直樹
  • Organizer: 日本環境変異原学会第38回大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-26
• [Presentation] マウスES細胞の神経系分化課程の評価試験系の確立と同過程における多環芳香族炭素類の影響評価 (2009)
  • Author(s): 清水久美子,久保田領志,田原麻衣子,小濱とも子,杉本直樹,西村哲治
  • Organizer: 第46回全国衛生化学技術協議会年会
  • Place of Presentation: 盛岡
  • Year and Date: 2009-11-13
• [Presentation] Toxicity of chlorinated benzo[a] pyrene (2009)
  • Author(s): Nishimura, T., Shimizu, K., Kubota, R., Sugimoto, N.
  • Organizer: 10^<th> International Conference on Environmental Mutagenes
  • Place of Presentation: Firenze, Italy
  • Year and Date: 2009-08-21