Research of Change in Pharmacokinetics as a Function of Age Intended Optimization of Drug Therapy in children

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590154
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: ISHIZAKI Junko 金沢大学, 薬学系, 准教授 (60401890)
• Co-Investigator(Kenkyū-buntansha): MIYAMOTO Ken-ichi 金沢大学, 附属病院, 教授 (30100514)
• Co-Investigator(Renkei-kenkyūsha): SUGA Yukio 金沢大学, 薬学系, 助教 (00467101)
• Project Period (FY): 2009 – 2011
• Keywords: 小児 / TDM / 適正使用 / ボリコナゾール / ミコフェノール酸 / バルプロ酸

Research Abstract

The changes in pharmacokinetics with aging of voriconazole, mycophenolic acid and valproate were investigated in human and rats. In all three drugs, pediatric patients were required a higher dose than adults to achive a similar the trough plasma concentration. I show that these differences are due to the activity of drug metabolism and the capacity of enterohepatic circulation, and suggest that changes of drug transpoter(s) expression over the course of development affect the disposition kinetics.

Research Products

• [Journal Article] Change in pharmacokinetics of mycophenolic acid as a function of age in rats and effect of coadministered amoxicillin/clavulanate (2012)
  • Author(s): Ishizaki, J., Tsuda, T., Suga, Y., Ito, S., Arai, K., Sai, Y., Miyamoto, K.
  • Journal Title: Biol. Pharm. Bull. Volume: (in press)
  • Peer Reviewed
• [Journal Article] 小児と成人におけるボリコナゾールの血中濃度解析の比較 (2010)
  • Author(s): 伊藤さつき, 石崎純子, 小柴美紀恵, 五十嵐康郎, 長田直人, 菅幸生, 西村良成, 前馬秀明, 小泉晶一, 中尾眞二, 横川弘一, 崔吉道, 宮本謙一
  • Journal Title: 医療薬学 Volume: 36 Pages: 213-219
  • Peer Reviewed
• [Presentation] 成長過程における抗てんかん薬バルプロ酸の薬物動態の変動 (2012)
  • Author(s): 東夏宵,石崎純子,菅幸生,荒井國三,崔吉道,宮本謙一
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-30
• [Presentation] バルプロ酸の血漿中濃度と肝機能との関係 (2012)
  • Author(s): 河辺志帆,石崎純子,東夏宵,菅幸生,荒井國三,崔吉道,宮本謙一
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-29
• [Presentation] 成長過程における免疫抑制剤ミコフェノール酸の体内動態変動 (2010)
  • Author(s): 石崎純子,津田智子,菅幸生,荒井國三,崔吉道,宮本謙一
  • Organizer: 第20回日本医療薬学会年会
  • Place of Presentation: 幕張メッセ国際展示場(千葉県)
  • Year and Date: 2010-11-13
• [Presentation] 小児における免疫抑制剤ミコフェノール酸の体内動態 (2009)
  • Author(s): 津田智子,石崎純子,小柴美紀恵,長田直人,菅幸生,荒井國三,西村良成,谷内江昭宏,崔吉道,宮本謙一
  • Organizer: 第19回日本医療薬学会年会
  • Place of Presentation: 長崎県立総合体育館(長崎県)
  • Year and Date: 2009-10-25
• [Remarks]
  • URL: http://www.p.kanazawa-u.ac.jp/lab/joho.html
• [Remarks]
  • URL: http://www.p.kanazawa-u.ac.jp/~druginfo/