2011 Fiscal Year Final Research Report
Study on the transportsome for ribavirin uptake in human erythrocyte membrane
| Project/Area Number |
21590162
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
RYOKO Yumoto 広島大学, 大学院・医歯薬学総合研究科, 助教 (70379915)
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| Co-Investigator(Renkei-kenkyūsha) |
MIKIHISA Takano 広島大学, 大学院・医歯薬学総合研究科, 教授 (20211336)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 赤血球膜 / 膜小胞 / ヌクレオチドトランスポーター / ウリジン / トランスポートソーム / リバビリン / 低温忍容性 |
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| Research Abstract |
The hemolytic anemia caused by ribavirin would be due to significant intracellular accumulation of the phosphorylated metabolites of ribavirin. Our research suggested that ribavirin uptake in ROVs of erythrocyte is mediated by equilibrative nucleoside transporter 1(ENT1). On one hand, ribavirin is not effluxed by ATP-dependent transporters. The human erythrocyte transporters such as ENT1 and glucose transporter function even at very low temperatures near 0°C.
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