2011 Fiscal Year Final Research Report
Systemic vascular disorders in chronic kidney disease and screening for protective drugs
| Project/Area Number |
21590172
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
ONO Takahiko 名古屋市立大学, 大学院・薬学研究科, 客員教授 (60243028)
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| Co-Investigator(Kenkyū-buntansha) |
MAKINO Toshiaki 名古屋市立大学, 大学院・薬学研究科, 准教授 (80326561)
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| Project Period (FY) |
2009 – 2011
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| Research Abstract |
We investigated effects of shichimotsukokato(SKT) on renal hypertension in rats subjected to a 5/6 nephrectomy(Nx). SKT significantly counteracted the increase in systolic blood pressure and plasma asymmetric dimethylarginine(ADMA) levels, and the decrease in plasma NO levels and renal dimethylarginine dimethylaminohydrolase(DDAH)-2 levels. It is considered that SKT reduced blood pressure mediated by the DDAH/ADMA/NO pathway.
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