2011 Fiscal Year Final Research Report
Proteomic analysis to find predictive markers for chemotherapeutic response, and basic study for biomarker development
| Project/Area Number |
21590176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
SUZUKI Sayo 慶應義塾大学, 薬学部, 講師 (90424134)
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| Co-Investigator(Kenkyū-buntansha) |
TANIGAWARA Yusuke 慶應義塾大学, 医学部, 教授 (30179832)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 個別化医療 / 抗がん剤 / 薬剤反応性 / バイオマーカー / プロテオーム / オキサリプラチン |
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| Research Abstract |
Predictive markers for chemotherapeutic response are urgently needed to improve the outcomes of cancer treatment. We have previously found that intracellular S100A10 is expected to be one of the candidate predictive markers for response to oxaliplatin, a key drug for the treatment of colorectal cancer(CRC). In this study, we have demonstrated, by using CRC cells, that S100A10 is more specific to L-OHP than 5-fluorouracil and suggested the possibility that the interaction of S100A10 and annexin A2, the binding partner of S100A10, is potentially involved in the chemoresistance.
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