2011 Fiscal Year Final Research Report
Morphological and molecular backgrounds for localization of ATP-induced signals in glial cells associated with cutaneous sensory devices.
| Project/Area Number |
21590206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 感覚神経終末 / 終末シュワン細胞 / カベオラ / カルシウム画像 / アデノシン5'三リン酸 |
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| Research Abstract |
Glial cells in cutaneous sensory devices extend multiple lamellar processes that cover different axon terminals and generate their own Ca^2+ signals in response to stimulation with the neurotransmitter ATP. We examined links between this glial signaling and the plasma membrane microdomains caveolae by immunohistochemistry and Ca^2+ image analysis in isolated lanceolate sensory endings. motion detectors of rat vibrissae. Our data have shown that caveola-dependent localization of the ATP receptor P2Y_2 and its coupling partner G_q/11 to the glial lamellae is essential for the subcellular compartmentalization of the signals.
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Research Products
(15 results)
