2011 Fiscal Year Final Research Report
Regulations of oxytocin receptor expression and estrogen action
| Project/Area Number |
21590253
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NARITA Kazumi 福井大学, 医学部, 助教 (80270958)
ICHIMARU Toru 福井大学, 医学部, 助教 (30452121)
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| Project Period (FY) |
2009 – 2011
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| Keywords | オキシトシン / オキシトシンレセプター / エストロジェン / エストロジェンレセプター / ラット |
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| Research Abstract |
The oxytocin receptor is regulated by estrogen secreted from the ovary. Using several types of estrogenic compound, the effects of estrogen on the oxytocin receptor were demonstarated to be mediated by several types of estrogen receptor, including classical estrogen receptorsαandβ, and the membrane-associated receptor. In addition, the brain site where estrogen shows an inhibitory effect on food intake was demonstrated in developing female rats.
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