2011 Fiscal Year Final Research Report
Examination of the effect of DIF, an inhibitor of G1 phase transition derived from Dictyostelium, as a new anti-cancer drug.
| Project/Area Number |
21590284
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Yutaka 愛媛大学, 理工学研究科, 教授 (40114722)
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| Co-Investigator(Renkei-kenkyūsha) |
MINAKO Hirahashi 九州大学, 大学病院, 医員 (90529877)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 抗腫瘍薬 / サイクリンD1 / G1期特異的 / Wntシグナル伝達経路 / モデル動物 |
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| Research Abstract |
Differentiation-inducing factor-1(DIF-1), a morphogen of Dictyostelium discoideum, shows anti-tumor effect in several human tumor cells in vitro. To evaluate whether DIF-1 is applicable for the treatment of tumor in vivo, the pharmacodynamics and the effect of DIF-1 in mice were analyzed.
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[Journal Article] DIF-1 Inhibits the Wnt/β-catenin Signaling Pathway by Inhibiting TCF7L2 Expression in Colon Cancer Cell Lines2012
Author(s)
Fan, X., TakahashiYanaga, F., Morimoto, S., Zhan, D.-Y., Igawa, K., Tomooka, K., & Sasaguri, T
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Journal Title
Biochemical Pharmacology
Volume: 83(1)
Pages: 47-56
DOI
Peer Reviewed
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[Journal Article] Celecoxib and 2, 5-dimethyl-celecoxib prevent cardiac remodeling inhibitiAkt-mediated signal transduction in an inherited DCM mouse model2011
Author(s)
Fan, X., Takahashi-Yanaga, F., Morimoto, S., Zhan, D.-Y., Igawa, K., Tomooka, K., & Sasaguri, T
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Journal Title
Exp. Ther
Volume: 338(1)
Pages: 2-11
DOI
Peer Reviewed
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[Journal Article] Anti-angiogenic effectdifferentiation-inducing factorinvolving VEGFR-2 expression inhibition independent of the Wnt/beta-catenin signaling pathway2010
Author(s)
Yoshihara, T., Takahashi-Yanaga, F., Shiraishi, F., Morimoto, S., Watanabe, Y., Hirata, M., Hoka, S., & SasaguriT
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Journal Title
Mol. Cancer
Volume: 9(1)
Pages: 245
Peer Reviewed
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[Journal Article] Dictyostelium differentiation-inducing factor-l binds to mitochondrial ma late dehydrogenase and inhibits its activity2010
Author(s)
Matsuda, T., Takahashi-Yanaga, F., Yoshihara, T., Maenaka, K., Watanabe, Y., Miwa, Y., Morimoto, S., Kubohara, Y., Hirata, M., & Sasaguri, T
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Journal Title
J. Pharmacol. Sci
Volume: 112(3)
Pages: 320-326
Peer Reviewed
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