2011 Fiscal Year Final Research Report
The function of mitochondrial CYP1A1 in the lipid metabolism.
| Project/Area Number |
21590319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生体分子医学 |
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| Research Abstract |
To understand the physiological functions of polycyclic aromatic hydrocarbons(PHAs) induced microsomal versus mitochondrial CYP1A1, it is the microsomal rather than mitochondrial CYP1A1 enzyme that protects against oral BaP toxicity. Because of metabolic delay of PHAs causes abnormal expression of transporter genes, PHAs is induced abnormal lipid metabolism. Our data support the likelihood that it is the microsomal rather than mitochondrial CYP1A1 enzyme that protects against PHAs induced mitochondrial dysfunction.
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Research Products
(2 results)
