2011 Fiscal Year Final Research Report
Regulatory mechanism of PML body function by MORC3
| Project/Area Number |
21590326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses |
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Principal Investigator |
INOUE Norimitsu 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 部長 (80252708)
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| Co-Investigator(Renkei-kenkyūsha) |
AKAZAWA Takashi 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 研究員 (80359299)
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| Research Collaborator |
TAKAHASHI Keiko Lawrence Berkeley National Laboratory, Postdoctoral fellow
MIMURA Yasuhiro 奈良先端科学技術大学院大学, 理化学研究所, 特別研究員
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| Project Period (FY) |
2009 – 2011
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| Keywords | MORC3 / PMLボディ / SUMO / 白血病 / 核ダイナミクス |
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| Research Abstract |
The PML-RARα fusion proteins cause acute promyelocytic leukemia(APL). The PML proteins form nuclear foci called PML-body in normal cells. However, PML-nuclear body is disrupted in APL cells. We focus on the localization mechanisms of MORC3 as a drug target of APL because the localization of MORC3 on PML-nuclear body is also disrupted in APL cells. In this study, we show that MORC3 colocalizes with PML by a two-step molecular mechanism.
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Research Products
(29 results)
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[Journal Article] Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors2012
Author(s)
Shime, H., Matsumoto, M., Oshiumi, H., Tanaka, S., Nakane, A., Iwakura, Y., Tahara, H., Inoue, N. and Seya, T.
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Journal Title
Proc. Natl. Acad. Sci
Volume: 109(6)
Pages: 2066-2071
DOI
Peer Reviewed
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[Journal Article] Deregulated expression of HMGA2 is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria2012
Author(s)
Murakami, Y., Inoue, N., Shichishima, T., Ohta, R., Noji, H., Maeda, Y., Nishimura, J., Kanakura, Y. and Kinoshita, T
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Journal Title
Brit. J. Haematology
Volume: 156(3)
Pages: 383-387
DOI
Peer Reviewed
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[Journal Article] Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR22011
Author(s)
Sawahata, R., Shime, H., Yamazaki, S., Inoue, N., Akazawa, T., Fujimoto, Y., Fukase, K., Matsumoto, M. and Seya, T.
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Journal Title
Microbes and Infection
Volume: 13
Pages: 350-358
DOI
Peer Reviewed
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[Journal Article] IL-23 dependent and-independent enhancement pathway of IL-17A production by lactic acid2011
Author(s)
Yabu, M., Shime, H., Hara, H., Saito, T., Matsumoto, M., Seya, T., Akazawa, T. and Inoue, N.
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Journal Title
Intl Immunology
Volume: 23(1)
Pages: 29-41
DOI
Peer Reviewed
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[Journal Article] Interferon-gamma markedly cooperates with intratumoral DC vaccine in dog tumor models2010
Author(s)
Mito, K., Sugiura, K., Ueda, K., Hori, T., Akazawa, T., Yamate, J., Hatoya, S., Inaba, M., Inoue, N., Ikehara, S. and Inaba, T.
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Journal Title
Cancer Research
Volume: 70(18)
Pages: 7093-7101
DOI
Peer Reviewed
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[Journal Article] Adjuvant engineering for cancer immunotherapy : Development of a synthetic TLR2 ligand with increased cell adhesion2010
Author(s)
Akazawa, T., Inoue, N., Shime, H., Kodama, K., Matsumoto, M. and Seya, T.
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Journal Title
Cancer Science
Volume: 101(7)
Pages: 1596-1603
DOI
Peer Reviewed
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[Journal Article] Effect of IL-12 on the canine dendritic cell maturation following differentiation induced by granulocyte-macrophage CSF and IL-42010
Author(s)
Sugiura, K., Wijewardana, V., Fujimoto, M., Akazawa, T., Yahata, M., Mito, K., Hatoya, S., Inoue, N. and Inaba, T
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Journal Title
Veterinary immunology and immunopathology
Volume: 137
Pages: 322-326
DOI
Peer Reviewed
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