2011 Fiscal Year Final Research Report
Plk1-mediated signaling pathway in cancer cells
Project/Area Number |
21590352
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Aichi Cancer Center Research Institute |
Principal Investigator |
GOTO Hidemasa 愛知県がんセンター(研究所), 発がん制御研究部, 室長 (20393126)
|
Project Period (FY) |
2009 – 2011
|
Keywords | Plk1 / 14-3-3ガンマ / チェックポイント / Chk1 |
Research Abstract |
Plk1 is known as one of mitotic kinases but its regulation remains largely unknown. In this study, we have demonstrated novel inverse relationship between Plk1 and checkpoint kinase 1(Chk1). We have also identified 14-3-3 gamma as a binding protein for Chk1 and Plk1. The binding between Chk1 and Plk1 is critical for cell cycle arrest in DNA damage response. Now, we are elucidating the significance of the binding between Plk1 and 14-3-3 gamma.
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[Journal Article] Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells2012
Author(s)
Inoko A., Matsuyama M., Goto H., Ohmuro-Matsuyama, Y., Hayashi Y., Enomoto M., Ibi M., Urano T., Shigenobu Y., Kiyono T., Izawa I., and Inagaki M.
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Journal Title
J. Cell Biol
Volume: 197
Pages: 391-405
DOI
Peer Reviewed
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[Journal Article] Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein2011
Author(s)
Ibi M., Zou P., Inoko A., Shiromizu T., Matsuyama M., Hayashi Y., Enomoto M., Mori D., Hirotsune S., Kiyono T., Tsukita S., Goto H., and Inagaki M.
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Journal Title
J. Cell Sci
Volume: 124
Pages: 857-864
DOI
Peer Reviewed
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[Journal Article] DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration and Tetraploidy Development2010
Author(s)
Ichijima Y., Yoshioka K.-I., Yoshioka Y., Shinohe K., Fujimori H., Unno J., Takagi M., Goto H., Inagaki M., Mizutani S., and Teraoka H.
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Journal Title
DOI
Peer Reviewed
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