2011 Fiscal Year Final Research Report
Epigenetic regulation of gene expression in AFP-producing gastric adenocarcinoma
Project/Area Number |
21590395
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Chiba University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Keywords | AFP産生胃癌 / エピジェネティック / GATA-4 |
Research Abstract |
AFP-producing adenocarcinoma is a highly malignant variant of the gastric cancer. GATA-4 is a gene that is involved in both gastrointestinal and hepatic differentiation. GATA-4 expression was restricted by DNA methylation in common-type gastric adenocarcinomas, whereas, we found that it was restricted by histone deacetylation in AFP-producing adenocarcinomas.
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