2011 Fiscal Year Final Research Report
Establishment of method to re-educate mecrophage differentiation towards dendritic cells on the view of regeneration medicine
| Project/Area Number |
21590416
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
SAIO Masanao 琉球大学, 医学部附属病院, 准教授 (40242721)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMI Tsuyoshi 岐阜大学, 大学院・医学系研究科, 教授 (70136943)
YOSHIMI Naoki 琉球大学, 大学院・医学研究科, 教授 (30166996)
TOMITA Mariko 琉球大学, 大学院・医学研究科, 准教授 (80381250)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腫瘍内マクロファージ / マウス |
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| Research Abstract |
Granulocyte macrophage colony stimulating factor(GM-CSF) treatment alone could not alter expression level of macrophage differentiation. On the other hands, when the TIM was treated with GM-CSF and siRNA for macrophage colony stimulating factor(M-CSF) receptor(M-CSFR) altered the expression of signal pathway proteins towards dendritic cell like feature. Above findings indicated we successfully re-educated(re-differentiated) TIM towards monocyte-derived dendritic cells like population and we showed the macrophage plasticity.
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