2011 Fiscal Year Final Research Report
Molecular mechanisms of promotion or suppression in renal tubular interstitial fibrosis
| Project/Area Number |
21590444
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 疾患モデル動物 / 線維化 / 上皮間葉転換 / TGF-β |
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| Research Abstract |
Mutations in TRPS1 cause tricho-rhino-pharyngeal syndrome. Trps1 is essential for nephron development, acting downstream of Bmp7. Because Bmp7 counteracts epithelial-to-mesenchymal transition(EMT) and reverses chronic renal injury, we examined the function of Trps1 in renal fibrosis. The results of the experiment suggest that Trps1 deficiency enhances TGF-b1-induced EMT and tubulointestinal fibrosis by modulating the amount of Smad7 through Arkadia/ubiquitin-mediated degradation.
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