2011 Fiscal Year Final Research Report
Recognition of Candida DNA and regulation of signaling by C type lectin receptor
| Project/Area Number |
21590489
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 感染免疫 |
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| Research Abstract |
The fungus Candida albicans colonizes the mucosal tissue of the oral cavity and the gastrointestinal tract, where it is part of the normal commensal microflora. However, under immune-compromised conditions, it can cause local and systemic candidiasis. To understand host defense mechanism against Candida, we analysed the interaction of signaling between TLR9 and dectin-2.As a result, we observed the collaborative induction of immune responses by these two receptors, which regulated the immunological status of the host during Candida albicans infection.
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